Ocular surface squamous neoplasia (OSSN) is an important ophthalmic public health problem in sub-Saharan Africa due to high levels of UV radiation and incidence of HIV/AIDS. Its occurrence is 10 times more in Africa than in other regions, affecting about 1.3 people per 100,000 population per year.There are 2 OSSN disease patterns: younger adults with a mean age of 40 years, predominantly women affected, and those that affect older adults with a mean age of 60 years and predominantly males. In recent times, chemotherapeutic agents such as 5-fluorouracil (5FU) have been used successfully in the treatment and as adjunct therapy of OSSN.